产品货号：
Z14020
中文名称：
CSNK1A1抗体
英文名称：
Anti-CSNK1A1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CSNK1A1 Antibody |
| 指标别名 | casein kinase 1;alpha 1;Casein kinase I isoform alpha;CK1;CKI alpha;CSNK1A1;HLCDGP1;PRO2975 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | CSNK1A1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human CSNK1A1 (30-68aa DIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQ),identical to the related mouse and rat sequences. |
| 实际分子量 | 35KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Casein kinase I isoform alpha is an enzyme that in humans is encoded by the°CSNK1A1 gene.The°CSNK1A1 gene is mapped to chromosome 5q32 based on an alignment of the°CSNK1A1 sequence with the genomic sequence (GRCh37).It is reported that both screens identified CK1-alpha as a bifunctional regulator of NF-kappa-B.CK1-alpha dynamically associates with the CBM complex on T cell receptor engagement to participate in cytokine production and lymphocyte proliferation.However,CK1-alpha kinase activity has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1.CK1-alpha has thus a dual 'gating' function which first promotes and then terminates receptor-induced NF-kappa-B.ABC DLBCL cells required CK1-alpha for constitutive NF-kappa-B activity,indicating that CK1-alpha functions as a conditionally essential malignancy gene. |
| Uniprot ID | P48729 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | casein kinase 1,alpha 1 |
| 蛋白名全称 | Casein kinase I isoform alpha |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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